Limnia depressa

https://thekeep.eiu.edu/herbarium_specimens_byname/18321/thumbnail.jp

Social work intervention with adults who self-neglect in England: responding to the Care Act 2014

Purpose – The paper reports on findings from an evaluative research study which looked at a timed intervention model of practice comprising of up to 24 weeks of intensive meetings with adult service users set up by one local authority in England, to prevent and delay the need for care and support. A particular focus of this paper is adults who hoard. Design/methodology/approach – The study employed a mixed-methods design, consisting of interviews with service users (n=13); social workers (n=3); social work managers (n=2); and stakeholders from external services and agencies (n=6). It included a costings analysis of staff time and an analysis of service users’ goals and of ‘satisfaction with life’ self-report questionnaires (n=20), completed at pre- and post-intervention stages. Findings – There was evidence that social workers used strengths, relationship-based and outcome-focused approaches in their work. The techniques used by social workers to engage, achieve change and assess effectiveness with service users varied. These included the use of photographs to enable the service user to map and assess their own progress over time, encouraging hoarders to declutter and reclaim their living space. The service users valued the time the social workers spent with them and the way that they were treated with sensitivity and respect. Research limitations/implications – The study focused on one local authority in England; there was no comparison group. This, and the small sample size, means that statistical generalisations cannot be made and only limited conclusions can be drawn from the quantitative data

Annual review of LCSPRs and rapid reviews

The system of rapid reviews and local child safeguarding practice reviews (LCSPRs) was established in 2018, to replace the previous system of serious case reviews. For a while the two systems ran alongside each other, but since October 2019, only the new system can be used. The Child Safeguarding Practice Review Panel (the Panel) published practice guidance in 2019 and its first Annual Report in 2020 (covering 2018-19). This present study, the first independent review of rapid reviews and LCSPRs, was undertaken by a joint team from the University of East Anglia and the University of Birmingham. Our aims were to provide an overview of key themes, issues and challenges for practitioners and agencies; draw out implications for policy makers and practitioners; assess how well the rapid reviews and LCSPRs achieve the tasks required of them; analyse the sample of LCSPRs available to us in order to increase understanding of the root causes of systemic strengths and vulnerabilities within local practice; and generate findings and questions for local safeguarding partners and the Panel to support them in their work to improve child protection practice

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.Peer reviewe

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder